Medima P300 -

The increasing demand for rapid, accurate, and decentralized medical care has spurred the development of point-of-care (POC) devices. However, most existing systems are siloed—diagnostic devices do not communicate directly with therapeutic ones, and data integration remains a bottleneck. This paper introduces the Medima P300 , a compact, portable, multi-modal platform designed to bridge this gap. The P300 integrates (1) a 12-lead ECG and continuous vital signs monitor, (2) a laser-based flow cytometry module for complete blood counts and inflammatory markers, (3) a surface-enhanced Raman spectroscopy (SERS) chip for pathogen and biomarker identification, and (4) a microfluidic closed-loop drug delivery system. Powered by an embedded edge-AI inference engine, the device can diagnose acute coronary syndrome, sepsis, and electrolyte imbalances within 12 minutes from a single fingerstick blood sample and non-contact sensors. In therapeutic mode, the P300 administers pre-filled, algorithm-controlled medication cartridges (e.g., vasopressors, antibiotics, insulin). We present the system architecture, validation data from a pilot study (N=150), and discuss regulatory pathways. The Medima P300 represents a paradigm shift towards autonomous, interoperable POC systems for emergency rooms, ambulances, and low-resource settings.

A. Hartley, PhD; S. Chen, MD; L. M. Rodriguez, PhD; K. I. Tanaka, MD (Affiliation: Institute for Integrated Medical Devices, University of Global Health) medima p300

The Medima P300: A Unified Point-of-Care Platform for Multi-Modal Biosensing, AI-Driven Diagnostics, and Closed-Loop Therapeutics in Critical and Remote Care The increasing demand for rapid, accurate, and decentralized

| Parameter | Specification | | :--- | :--- | | Dimensions | 250 × 180 × 70 mm | | Weight | 3.2 kg (including battery) | | Power | Internal Li-ion (14.4 V, 6800 mAh); AC adapter 100–240 V | | Operating temperature | 10–40 °C, 15–90% RH non-condensing | | Blood sample volume | 150 µL (capillary or venous) | | Time to results | 12 minutes (full panel), 5 minutes (vitals + glucose only) | | Drug cartridge volume | 10 mL per cartridge (up to 2 cartridges) | | Infusion accuracy | ±5% at 0.5–100 mL/h | | Connectivity | USB-C (data), Bluetooth 5.2 (optional), no Wi-Fi/cellular | The P300 integrates (1) a 12-lead ECG and

PATIENT: ID-7890, F/72 TIME: 2026-04-17 10:34:22 UTC VITALS: HR 118 bpm (SVT), BP 88/52, RR 24, SpO2 93%, Temp 38.9°C BLOOD PANEL: Na 132 ↓, K 4.1, Glu 145 ↑, Lac 3.2 ↑, CRP 145 mg/L ↑, PCT 8.2 ng/mL ↑ WBC 18.5 ↑, Plt 98 ↓ SERS: LPS detected (E. coli, 95% confidence)

Dr. Hartley is a paid consultant to Medima Health, Inc. Other authors declare no competing interests.

This work was funded by the Global Health Innovation Fund (Grant GH-2024-089). The authors thank the ED staff of University Hospital North and the rural health posts of Kilifi County, Kenya.